Publications

Peer Reviewed

Webler, R. D., Oathes, D. J., van Rooij, S. J. H., Gewirtz, J. C., Nahas, Z., Lissek, S., & Widge, A. S. (2023). Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods. Neuroscience and biobehavioral reviews, 144, 105005. https://doi.org/10.1016/j.neubiorev.2022.105005

Keefe, J. R., Suarez-Jimenez, B., Zhu, X., Lazarov, A., Durosky, A., Such, S., Marohasy, C., Lissek, S., & Neria, Y. (2022). Elucidating behavioral and functional connectivity markers of aberrant threat discrimination in PTSD. Depression and anxiety, 39(12), 891–901. https://doi.org/10.1002/da.23295

Zhu, X., Suarez-Jimenez, B., Lazarov, A., Such, S., Marohasy, C., Small, S. S., Wager, T. D., Lindquist, M. A., Lissek, S., & Neria, Y. (2022). Sequential fear generalization and network connectivity in trauma exposed humans with and without psychopathology. Communications biology, 5(1), 1275. https://doi.org/10.1038/s42003-022-04228-5

Manbeck, A. B., Cooper, S. E., & Lissek, S. (2022). Reversing threat contingencies enhances generalization of conditioned fear. Learning and Motivation, 80, 101843. https://doi.org/10.1016/j.lmot.2022.101843

Korem, N., Duek, O., Ben-Zion, Z., Kaczkurkin, A. N., Lissek, S., Orederu, T., Schiller, D., Harpaz-Rotem, I., & Levy, I. (2022). Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 47(11), 1913–1921. https://doi.org/10.1038/s41386-022-01405-2

Cooper, S. E., van Dis, E. A. M., Hagenaars, M. A., Krypotos, A. M., Nemeroff, C. B., Lissek, S., Engelhard, I. M., & Dunsmoor, J. E. (2022). A meta-analysis of conditioned fear generalization in anxiety-related disorders. Neuropsychopharmacology, 47(9), 1652–1661. https://doi.org/10.1038/s41386-022-01332-2

Hunt, C., Fleig, R., Almy, B., & Lissek, S. (2022). Heightened false alarms of conditioned threat predict longitudinal increases in GAD and SAD symptoms over the first year of college. Journal of anxiety disorders, 87, 102539. https://doi.org/10.1016/j.janxdis.2022.102539

Hunt, C., Webler, R., Emich, A., Fhong, K., Hiljus, J., & Lissek, S. (2022). Pre-COVID-19 fear conditioning responses predict COVID-19-related anxiety: evidence from an exploratory study. Anxiety, stress, and coping, 35(5), 547–556. https://doi.org/10.1080/10615806.2022.2033735

Cooper, S. E., Hunt, C., Stasik-O'Brien, S. M., Berg, H., Lissek, S., Watson, D., & Krueger, R. F. (2022). The placement of obsessive-compulsive symptoms within a five-factor model of maladaptive personality. Assessment, 10731911211070623. Advance online publication. https://doi.org/10.1177/10731911211070623

Cooper, S. E., Hunt, C., Ross, J. P., Hartnell, M. P., & Lissek, S. (2022). Heightened generalized conditioned fear and avoidance in women and underlying psychological processes. Behaviour research and therapy, 151, 104051. Advance online publication. https://doi.org/10.1016/j.brat.2022.104051

Hunt, C., Degeneffe, N., Bixby, J., & Lissek, S. (2022). Obsessive Compulsive Symptoms Are Associated With Heightened Avoidance of Low-Probability, High-Aversion Threats: A Preliminary Test of the Improbable-Catastrophe Hypothesis. Clinical Psychological Science, 10(3), 514-533. https://doi.org/10.1177/2167702621103486

Berg, H., Hunt, C., Cooper, S. E., Olatunji, B. O., & Lissek, S. (2021). Generalization of conditioned disgust and the attendant maladaptive avoidance: Validation of a novel paradigm and effects of trait disgust-proneness. Behaviour research and therapy, 146, 103966. https://doi.org/10.1016/j.brat.2021.103966

Polusny, M. A., Marquardt, C. A., Campbell, E. H., Filetti, C. R., Noël, V. V., Disner, S. G., Schaefer, J. D., Davenport, N., Lissek, S., Noorbaloochi, S., Sponheim, S. R., & Erbes, C. R. (2021). Advancing Research on Mechanisms of Resilience (ARMOR) Longitudinal Cohort Study of New Military Recruits: Results from a Feasibility Pilot Study. Research in human development, 18(3), 212–229. https://doi.org/10.1080/15427609.2021.1964898

Webler, R. D., Berg, H., Fhong, K., Tuominen, L., Holt, D. J., Morey, R. A., Lange, I., Burton, P. C., Fullana, M. A., Radua, J., & Lissek, S. (2021). The neurobiology of human fear generalization: meta-analysis and working neural model. Neuroscience and biobehavioral reviews, 128, 421–436. https://doi.org/10.1016/j.neubiorev.2021.06.035

Berg, H., Ma, Y., Rueter, A., Kaczkurkin, A., Burton, P. C., DeYoung, C. G., MacDonald, A. W., Sponheim, S. R., & Lissek, S. (2021). Salience and central executive networks track overgeneralization of conditioned-fear in post-traumatic stress disorder. Psychological medicine, 51(15), 2610–2619. https://doi.org/10.1017/S0033291720001166

Albott, C. S., Lee, S., Cullen, K. R., Thuras, P., Lissek, S., Wels, J., Friedrich, K. J., Krueger, A. M., & Lim, K. O. (2021). Characterization of Comorbid Posttraumatic Stress Disorder and Major Depressive Disorder Using Ketamine as an Experimental Medicine Probe ^†. Journal of psychiatry and brain science, 6, e210012. https://doi.org/10.20900/jpbs.20210012

Sun, M., Marquardt, C., Disner, S., Burton, P., Davenport, N., Lissek, S., & Sponheim, S. (2020). Posttraumatic stress symptomatology and abnormal neural responding during emotion regulation under cognitive demands: Mediating effects of personality. Personality Neuroscience, 3, E9. doi:10.1017/pen.2020.10

Shukla, M., Lau, J. Y. F., Lissek, S., Pandey, R., & Kumari, V. (2020). Reduced emotional responsiveness in individuals with marginal elevation in blood pressure within the normal range: Evidence from altered affect-modulated startle response. International Journal of Psychophysiology, 153, 18-26. https://doi.org/10.1016/j.ijpsycho.2020.04.013

Berg, H., Ma, Y., Rueter, A., Kaczkurkin, A., Burton, P. C., DeYoung, C. G., MacDonald, A., Sponheim, S. R., & Lissek, S. (Accepted/In press). Salience and central executive networks track overgeneralization of conditioned-fear in post-traumatic stress disorder. Psychological medicine. https://doi.org/10.1017/S0033291720001166

Hammell, A. E., Helwig, N. E., Kaczkurkin, A. N., Sponheim, S. R., & Lissek, S. (2020). The temporal course of over-generalized conditioned threat expectancies in posttraumatic stress disorder. Behaviour Research and Therapy, 124, [103513]. https://doi.org/10.1016/j.brat.2019.103513

Hunt, C., Cooper, S.E, Hartnell, M.P., & Lissek, S. (2019). Anxiety sensitivity and intolerance of uncertainty facilitate associations between generalized Pavlovian fear and maladaptive avoidance decisions. Journal of Abnormal Psychology, 128, 315-326.

Lange, I., Goossens, L., Bakker, J., Michielse, S., van Winkel, R., Lissek, S., Leibold, N.,  Marcelis, M., Wichers, M., van Os, J., van Amelsvoort, T., & Schruers, K. (2019). Neurobehavioural mechanisms of threat generalization moderate the link between childhood maltreatment and psychopathology in emerging adulthood. Journal of Psychiatry & Neuroscience, 44, 185-194.

Cooper, S.E., & Lissek, S.L. (2018). Impaired discriminative fear conditioning during later training trials differentiates generalized anxiety disorder, but not panic disorder, from healthy control participants. Comprehensive Psychiatry, 85, 84-93.

Marquardt, C. A., Goldman, D. J., Cuthbert, B. N., Lissek, S., & Sponheim, S. R. (2018). Symptoms of Posttraumatic Stress Rather Than Mild Traumatic Brain Injury Best Account for Altered Emotional Responses in Military Veterans. Journal of Traumatic Stress, 31(1), 114-124. https://doi.org/10.1002/jts.22259

Hunt, C., Cooper, S. E., Hartnell, M. P., & Lissek, S. (2017). Distraction/suppression and Distress Endurance diminish the extent to which generalized conditioned fear is associated with maladaptive behavioral avoidance. Behaviour Research and Therapy.

Lange I, Goossens L, Michielse S, Bakker J, Lissek S, Papalini S, Verhagen S, Leibold N, Marcelis M, Wichers M, Lieverse R, van Os J, van Amelsvoort T, Schruers K. (2017). Behavioral pattern separation and its link to the neural mechanisms of fear generalization. Social Cognitive and Affective Neuroscience. doi: 10.1093/scan/nsx104.

Kaczkurkin, A.N., Burton, P.C., Chazin, S.M., Manbeck, A.B., Espensen-Sturges, T., Cooper, S.E., Sponheim, S.R., & Lissek, S. (2017). Neural substrates of over-generalized conditioned fear in posttraumatic stress disorder. American Journal of Psychiatry.

Lissek, S., van Meurs, B. (2015). Learning models of PTSD: Theoretical accounts and psychobiological evidence. International Journal of Psychophysiology.

Duits, P., Cath, D.C., Lissek, S., Hox, J.J., Hamm, A. O., van de Hout, M.A., Engelhard, I.M. & Baas, J.M.P. (2015). An updated meta-analysis of classical fear-conditioning in the anxiety disorders. Depression and Anxiety, 32, 239-253.

Lissek, S., Bradford, D.E., Alvarez, R.P., Burton, P., Espensen-Sturges, T., Reynolds, R.C., and Grillon, C. (2014). Neural substrates of classically conditioned fear-generalization in humans: A parametric fMRI study. Social Cognitive and Affective Neuroscience, 9, 1134-42. 

Lissek, S., Kaczkurkin, A.N., Rabin, S., Geraci, M., Pine, D.S., and Grillon, C. (2014). Generalized anxiety disorder is associated with overgeneralization of classically conditioned-fear. Biological Psychiatry, 75, 909-915.

Van Meurs, B., Wiggert, N., Wicker, I., Lissek, S. (2014). Maladaptive behavioral consequences of conditioned fear-generalization: A pronounced, yet sparsely studied, feature of anxiety pathology. Behaviour Research and Therapy, 57, 29-37.

Kaczkurkin, A.N, Lissek, S. (2013). Generalization of conditioned fear in individuals with high and low obsessive-compulsive traits. Journal of Psychology & Psychotherapy. S7: 003, 1-7.

Britton, J., Grillon, C., Lissek, S., Norcross, M.A., Szuhany, K.L., Chen, G., Ernst, M., Nelson, E.E., Leibenluft, E., Shechner, T., Pine, D.S. (2013). Response to learned threat: An fMRI study in adolescent and adult anxiety. American Journal of Psychiatry, 170, 1195-1204.

Lissek, S. (2012). Toward an account of clinical anxiety predicated on basic, neurally mapped mechanisms of Pavlovian fear-learning. Depression and Anxiety.

Haddad, A.D.M., Pritchett, D., Lissek, S., Lau, J.Y.F. (in press). Trait Anxiety and Fear Responses to Safety Cues: Stimulus Generalization or Sensitization? Journal of Psychopathology and Behavioral Assessment.

Glenn, C. R., Klein, D. N., Lissek, S., Britton, J. C., Pine, D. S., & Hajcak, G. (2012). The development of fear learning and generalization in 8 to 13 year-olds. Developmental Psychobiology

Haddad,. A.D., Lissek, S., Pine, D.S., Lau, J.Y. (2011). How do social fears in adolescence develop? Fear conditioning shapes attention orienting to social threat cues. Cognition and Emotion, 25, 1139-1147.

Cornwell, B.R., Alvarez, R.P., Lissek, S., Kaplan, R., Ernst, M., Grillon, C. (2011). Anxiety overrides the blocking effects of high perceptual load on amygdala reactivity to threat-related distractors. Neuropsychologia, 49, 1363-1368.

Lau, J.Y.F., Nelson, E.E., Angold, A., Britton, J., Ernst, M., Goldwin, M., Grillon, C., Lissek, S., Shiffrin, N., Pine, D.S. (2011). Distinct neural signatures of threat learning in adolescents and adults. Proceedings of the National Academy of Sciences, 108, 4500-4505.

Britton, J.C., Lissek, S., Grillon, C., Norcross, M.A., & Pine, D.S. (2011). Development of anxiety: The role of threat appraisal and fear learning. Depression and Anxiety, 28, 5-17.

Hakamata, Y., Lissek, S., Bar-Haim, Y., Britton, J.C., Fox, N., Leibenluft, E., Ernst, M., & Pine, D.S. (2010). Attention Bias Modification Treatment: A meta-analysis towards the establishment of novel treatment for anxiety. Biological Psychiatry, 68, 982-990.

Lissek S. & Grillon C. (2010). Overgeneralization of conditioned fear in the anxiety disorders: Putative memorial mechanisms.Journal of Psychology, 218, 146-148.

Lissek, S., Rabin, S.J., Heller, R.E., Luckenbaugh, D., Geraci, M., Pine, D.S., & Grillon, C. (2010). Overgeneralization of conditioned fear as a pathogenic marker of panic disorder.American Journal of Psychiatry, 167, 47-55.

Lissek, S., Rabin, S. J., McDowell, D.J., Dvir, S., Bradford, D. E., Geraci, M., Pine, D.S., & Grillon, C. (2009). Impaired discriminative fear-conditioning resulting from elevated fear-responding to learned safety cues among individuals with panic disorder. Behaviour Research and Therapy, 47, 111-118.

Powers, A.S., Hogue, P., Lynch, C., Gattuso, B., Lissek, S., & Nayal, C. (2009). Role of acetylcholine in negative patterning in turtles (Chrysemys picta). Behavioral Neuroscience, 123, 804-809.

Reeb, B.C., Helfinstein, S.M., Perez-Edgar, K., Henderson, H.A., Lissek, S., Grillon, C., Pine, D.S., & Fox, N.A. (2009). Startle response in behaviorally inhibited adolescents with a lifetime occurrence of anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 610-617.

Grillon, C., Pine, D.S., Lissek, S., Rabin, S., & Vythilingam, M. (2009). Increased anxiety during anticipation of unpredictable aversive stimuli in posttraumatic stress disorder but not in generalized anxiety disorder. Biological Psychiatry, 66, 47-53.

Lissek, S., Levenson, J., Biggs, A., Johnson, L., Ameli, R., Pine, D.S., & Grillon, C. (2008). Social anxiety disorder is associated with elevated fear-conditioning to socially relevant unconditioned stimuli. American Journal of Psychiatry, 165, 124-32.

Lissek, S., Biggs, A.L., Rabin, S., Cornwell, B.R., Alvarez, R.P., Pine, D.S., & Grillon, C. (2008). Generalization of conditioned fear-potentiated startle in humans: Experimental validation and clinical relevance. Behaviour Research and Therapy, 46, 678-87.

Grillon, C., Lissek, S., Rabin, S., McDowell, D., Dvir, S., & Pine, D.S. (2008). Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder. American Journal of Psychiatry, 165, 898-904.

Lau, J.Y.F., Lissek, S., Nelson, E., Lee, Y., Roberson-Nay, R., Poeth, K., Jenness, J., Ernst, M., Grillon, C., & Pine, D.S. (2008). Fear conditioning in adolescents with anxiety disorders: Results from a novel experimental paradigm. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 94-102.

Lissek, S., Orme, K., McDowell, D.J., Johnson, L.L., Luckenbaugh, D., & Grillon, C. (2007). Emotion regulation and potentiated startle across affective picture and threat of shock paradigms. Biological Psychology, 76, 124-133.

Cornwell, B.R., Baas, J.M.P., Johnson, L., Holroyd, T., Carver, F., Mitchell-Francis, J., Lissek, S., & Grillon, C. (2007). Neural responses to auditory stimulus deviance under threat of electric shock revealed by spatially-filtered magnetoencephalography. NeuroImage, 37, 282-289.

Grillon C, Lissek S, McDowell D, Levenson J, & Pine DS (2007). Reduction of trace but not delay eyeblink conditioning in panic disorder. American Journal of Psychiatry, 164, 283-289.

Lissek, S., Pine, D.S., & Grillon, C. (2006). The strong situation: A potential impediment to studying the psychobiology and pharmacology of anxiety disorders. Biological Psychology, 72, 265-270.

Grillon, C., Baas, J.M.P., Pine, D. S., Lissek, S., Lawley, M., Ellis, V., & Levine, J. (2006). The benzodiazepine alprazolam dissociates contextual fear from cued fear in humans as assessed by fear-potentiated startle. Biological Psychiatry, 60, 760-766.

Lissek, S., Baas, J.M.P., Pine, D., Orme, K., Dvir, S., Rosenberger, E., & Grillon, C. (2005). Sensation seeking and the aversive motivational system. Emotion, 5, 396-407.

Lissek, S., Powers, A.S., McClure, E.B., Phelps, E.A., Woldehawariat, G., Grillon, C., & Pine, D.S. (2005). Classical fear-conditioning in the anxiety disorders: A meta-analysis.Behaviour Research and Therapy, 43, 1391-1424.

Lissek, S., Baas, J.M.P., Pine, D.S., Orme, K., Dvir, S., Nugent, M., Rosenberger, E., Rawson, E. & Grillon, C. (2005). Airpuff startle probes: An efficacious and less aversive alternative to white-noise. Biological Psychology, 68, 283-297.

Hasler, G., Lissek, S., Ajdacic,V., Milos, G., Gamma, A., Eich, D., Rössler, W., & Angst, J. (2005). Major depression predicts an increase in long-term body weight variability in young adults: A twenty year prospective community study. Obesity Research, 13, 1991-8.

Pine, D.S., Klein, R.G., Mannuzza, S., Moulton, J.L. 3rd, Lissek, S., Guardino, M. & Woldehawariat, G. (2005). Face-Emotion Processing in Offspring at Risk for Panic Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 664-672.

Pine, D.S., Lissek, S., Klein, R.G., Mannuzza, S., Moulton, J.L., 3rd, Guardino, M. & Wodehawariat, G. (2004). Face-memory and emotion: Associations with major depression in children and adolescents. Journal of Child Psychology and Psychiatry, 45, 1199-1208.

Grillon, C., Baas, J.M.P., Lissek, S., Smith, K., & Milstein, J. (2004). Anxious responses to predictable and unpredictable aversive events. Behavioral Neuroscience, 118, 916-924.

Baas, J.M.P., Nugent, M., Lissek, S., Pine, D.S., & Grillon, C. (2004). Fear conditioning in virtual reality contexts: A new tool for the study of anxiety. Biological Psychiatry, 55, 1056-1060.

Lissek, S. & Powers, A.S. (2003). Sensation seeking and startle modulation by physically threatening images. Biological Psychology, 63, 179-97.

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